The Hematopoietic Niche in Myeloproliferative Neoplasms
نویسندگان
چکیده
منابع مشابه
The Hematopoietic Niche in Myeloproliferative Neoplasms
Specialized microanatomical areas of the bone marrow provide the signals that are mandatory for the maintenance and regulation of hematopoietic stem cells (HSCs) and progenitor cells. A complex microenvironment adjacent to the marrow vasculature (vascular niche) and close to the endosteum (endosteal niche) harbors multiple cell types including mesenchymal stromal cells and their derivatives suc...
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A decade on from the description of JAK2 V617F, the MPNs are circumscribed by an increasingly intricate landscape. There is now evidence that they are likely the result of combined genetic dysregulation, with several mutated genes involved in the regulation of epigenetic mechanisms. Epigenetic changes are not due to a change in the DNA sequence but are reversible modifications that dictate the ...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2015
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2015/347270